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Outcomes and Risk Factors for Cardiovascular Events in Hospitalized COVID-19 Patients.

Authors
  • Xu, Qian1
  • Samanapally, Harideep2
  • Nathala, Pavani2
  • Salunkhe, Vidyulata2
  • Furmanek, Stephen2
  • Cahill, Meredith N3
  • McGuffin, Trevor4
  • Mohammad, Tahboub2
  • Marsili, Bradford5
  • Petrey, Jessica6
  • Carrico, Ruth2
  • Ramirez, Julio2
  • Akca, Ozan5
  • Clifford, Sean P5
  • Pahwa, Siddharth7
  • Roser, Lynn4
  • Kong, Maiying1
  • Huang, Jiapeng8
  • 1 Department of Bioinformatics and Biostatistics, School of Public Health and Information Sciences, University of Louisville, Louisville, KY.
  • 2 Division of Infectious Diseases, Center of Excellence for Research in Infectious Diseases (CERID), University of Louisville, Louisville, KY.
  • 3 Division of Infectious Diseases, Center of Excellence for Research in Infectious Diseases (CERID), University of Louisville, Louisville, KY; School of Medicine, University of Louisville, Louisville, KY.
  • 4 School of Nursing, University of Louisville, Louisville, KY.
  • 5 Department of Anesthesiology & Perioperative Medicine, University of Louisville, Louisville, KY.
  • 6 Kornhauser Health Sciences Library, University of Louisville, Louisville, KY.
  • 7 Department of Cardiovascular & Thoracic Surgery, University of Louisville, Louisville, KY.
  • 8 Division of Infectious Diseases, Center of Excellence for Research in Infectious Diseases (CERID), University of Louisville, Louisville, KY; Department of Anesthesiology & Perioperative Medicine, University of Louisville, Louisville, KY; Department of Cardiovascular & Thoracic Surgery, University of Louisville, Louisville, KY; Center for Integrative Environmental Health Sciences, University of Louisville, Louisville, KY. Electronic address: [email protected]
Type
Published Article
Journal
Journal of cardiothoracic and vascular anesthesia
Publication Date
Dec 01, 2021
Volume
35
Issue
12
Pages
3581–3593
Identifiers
DOI: 10.1053/j.jvca.2021.03.035
PMID: 33867235
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To analyze outcomes and risk factors of cardiovascular events in a metropolitan coronavirus disease 2019 (COVID-19) database, and to perform a subgroup analysis in African American populations to determine whether outcomes and risk factors are influenced by race. Retrospective cohort analysis from March 9, 2020 to June 20, 2020. Population-based study in Louisville, KY, USA. Seven hundred adult inpatients hospitalized with COVID-19. N/A. This cohort consisted of 126 patients (18%) with cardiovascular events and 574 patients without cardiovascular events. Patients with cardiovascular events had a much higher mortality rate than those without cardiovascular events (45.2% v 8.7%, p < 0.001). There was no difference between African American and white patients regarding mortality (43.9% v 46.3%, p = 1) and length of stay for survivors (11 days v 9.5 days, p = 0.301). Multiple logistics regression analysis suggested that male, race, lower SaO2/FIO2, higher serum potassium, lower serum albumin, and number of cardiovascular comorbidities were highly associated with the occurrence of cardiovascular events in COVID-19 patients. Lower serum albumin and neoplastic and/or immune-compromised diseases were highly associated with cardiovascular events for African American COVID-19 patients. SaO2/FIO2 ratio and cardiovascular comorbidity count were significantly associated with cardiovascular events in white patients. Cardiovascular events were prevalent and associated with worse outcomes in hospitalized patients with COVID-19. Outcomes of cardiovascular events in African American and white COVID-19 patients were similar after propensity score matching analysis. There were common and unique risk factors for cardiovascular events in African American COVID-19 patients when compared with white patients. Copyright © 2021 Elsevier Inc. All rights reserved.

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