Affordable Access

deepdyve-link
Publisher Website

Outcomes of pregnancies complicated by liver cirrhosis, portal hypertension, or esophageal varices.

Authors
  • Puljic, Anela1
  • Salati, Jennifer2
  • Doss, Amy2
  • Caughey, Aaron B2
  • 1 a Department of Reproductive Medicine , University of California , San Diego , CA , USA and.
  • 2 b Department of Obstetrics & Gynecology , Oregon Health & Science University , Portland , OR , USA.
Type
Published Article
Journal
The Journal of Maternal-Fetal & Neonatal Medicine
Publisher
Informa UK (Taylor & Francis)
Publication Date
Jan 01, 2016
Volume
29
Issue
3
Pages
506–509
Identifiers
DOI: 10.3109/14767058.2015.1009438
PMID: 25655526
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To evaluate pregnancy outcomes in women with liver cirrhosis, portal hypertension, or esophageal varices. We analyzed a retrospective cohort of 2,284,218 pregnancies in 2005-2009 recorded in the California Birth Registry database. Utilizing ICD-9 codes we analyzed the following outcomes for liver cirrhosis, portal hypertension, or esophageal varices in pregnancy: preeclampsia (PET), preterm delivery (PTD; <37 weeks), cesarean section, low birth weight (LBW; <2500 g), small for gestational age (SGA; <10th percentile), neonatal death (NND), and postpartum hemorrhage (PPH). Cirrhosis in pregnancy conferred an increased risk of PET, PTD, CS in multiparous women, LBW, and NND. Portal hypertension in pregnancy was associated with PTD, LBW, NND, and PPH. Non-bleeding esophageal varices in pregnancy were not associated with the outcomes assessed in a statistically significant manner. One case of bleeding esophageal varices was observed, resulting in PTD with a LBW infant. There were three cases of concomitant portal hypertension or concomitant esophageal varices with cirrhosis in pregnancy. Pregnancy in women with concomitant liver cirrhosis, portal hypertension, or esophageal varices can be successful. However, pregnancy outcomes are worse and may warrant closer antenatal monitoring and patient counseling. Cirrhosis in pregnancy with concomitant portal hypertension or esophageal varices is rare.

Report this publication

Statistics

Seen <100 times