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The outcomes of adrenalectomy for solitary adrenal metastasis: A 17-year single-center experience.

Authors
  • Hatano, Koji1
  • Horii, Sayaka1
  • Nakai, Yasutomo1
  • Nakayama, Masashi1
  • Kakimoto, Ken-Ichi1
  • Nishimura, Kazuo1
  • 1 Department of Urology, Osaka International Cancer Institute, Osaka, Japan. , (Japan)
Type
Published Article
Journal
Asia-Pacific journal of clinical oncology
Publication Date
Apr 01, 2020
Volume
16
Issue
2
Identifiers
DOI: 10.1111/ajco.13078
PMID: 30270570
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

We aimed to analyze surgical outcomes of open or laparoscopic adrenalectomy for solitary adrenal metastasis and assess the factors influencing survival. We retrospectively reviewed our institutional clinicopathological database for cases of adrenalectomy for solitary adrenal metastasis from solid tumors between 2000 and 2017. Twenty-five patients underwent open adrenalectomy (n = 11) or laparoscopic adrenalectomy (n = 14). The most common primary site was the lung (n = 7), followed by the kidney (n = 5), liver (n = 3), ovary (n = 2), soft tissue (n = 2), and six other sites. The majority of the patients (n = 19) had metachronous metastasis. The median tumor size was 3.1 cm (1-9 cm). With the median follow-up of 32 months (2-144 months), the median progression-free and overall survivals were 14 and 63 months, respectively. Multivariate analysis revealed that synchronous metastasis (hazard ratio [HR] = 7.5) and tumor size ≥ 4 cm (HR = 17.7) were significant prognostic factors for shorter overall survival. There was no significant difference for survival between the laparoscopic and open groups. Adrenalectomy for solitary adrenal metastasis can be applied for selected patients with various types of malignancy. However, synchronous metastasis and tumor size ≥ 4 cm were prognostic factors for shorter overall survival. © 2018 John Wiley & Sons Australia, Ltd.

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