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Out of synch: Clock mutation causes obesity in mice.

Authors
  • Williams, Diana L
  • Schwartz, Michael W
Type
Published Article
Journal
Cell Metabolism
Publisher
Elsevier
Publication Date
Jun 01, 2005
Volume
1
Issue
6
Pages
355–356
Identifiers
PMID: 16054082
Source
Medline
License
Unknown

Abstract

The Clock gene encodes an essential component of the "master clock" driving circadian rhythm in the hypothalamic suprachiasmatic nucleus (SCN). New evidence that Clock mutant mice are hyperphagic and obese suggests a previously unrecognized link between molecular controls of circadian rhythm and energy homeostasis.

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