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Osteoconductive Amine-Functionalized Graphene-Poly(methyl methacrylate) Bone Cement Composite with Controlled Exothermic Polymerization.

Authors
  • Sharma, Rakesh
  • Kapusetti, Govinda1
  • Bhong, Sayali Yashwant1
  • Roy, Partha2
  • Singh, Santosh Kumar3
  • Singh, Shikha4
  • Balavigneswaran, Chelladurai Karthikeyan...
  • Mahato, Kaushal Kumar
  • Ray, Biswajit4
  • Maiti, Pralay
  • Misra, Nira
  • 1 Department of Medical Devices, National Institute of Pharmaceutical Education and Research , Ahmedabad 380054, India. , (India)
  • 2 Department of Biotechnology, Indian Institute of Technology , Roorkee 247667, India. , (India)
  • 3 Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University , Varanasi 221005, India. , (India)
  • 4 Department of Chemistry, Banaras Hindu University , Varanasi 221005, India. , (India)
Type
Published Article
Journal
Bioconjugate Chemistry
Publisher
American Chemical Society
Publication Date
Sep 20, 2017
Volume
28
Issue
9
Pages
2254–2265
Identifiers
DOI: 10.1021/acs.bioconjchem.7b00241
PMID: 28753275
Source
Medline
License
Unknown

Abstract

Bone cement has found extensive usage in joint arthroplasty over the last 50 years; still, the development of bone cement with essential properties such as high fatigue resistance, lower exothermic temperature, and bioactivity has been an unsolved problem. In our present work, we have addressed all of the mentioned shortcomings of bone cement by reinforcing it with graphene (GR), graphene oxide (GO), and surface-modified amino graphene (AG) fillers. These nanocomposites have shown hypsochromic shifts, suggesting strong interactions between the filler material and the polymer matrix. AG-based nanohybrids have shown greater osteointegration and lower cytotoxicity compared to other nanohybrids as well as pristine bone cement. They have also reduced oxidative stress on cells, resulting in calcification within 20 days of the implantation of nanohybrids into the rabbits. They have significantly reduced the exothermic curing temperature to body temperature and increased the setting time to facilitate practitioners, suggesting that reaction temperature and settling time can be dynamically controlled by varying the concentration of the filler. Thermal stability and enhanced mechanical properties have been achieved in nanohybrids vis-à-vis pure bone cement. Thus, this newly developed nanocomposite can create natural bonding with bone tissues for improved bioactivity, longer sustainability, and better strength in the prosthesis.

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