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Osmotic ultrafiltration with dextran sodium sulfate potential for use in peritoneal dialysis.

Authors
  • Rubin, J
  • Nolph, K
  • McGary, T
Type
Published Article
Journal
Journal of dialysis
Publication Date
Jan 01, 1979
Volume
3
Issue
2-3
Pages
251–264
Identifiers
PMID: 512180
Source
Medline
License
Unknown

Abstract

Dextran sodium sulfate was evaluated in vitro as a potential non-absorbable osmotic agent for peritoneal dialysis. It was compared to poly(sodium acrylate) which has been shown previously to be effective in rats, but probably toxic. Dextran sodium sulfate induced osmotic ultrafiltration rates as high as 20 ml/min in water but only 2 ml/min in solution containing non-polymer electrolytes presumably because of Gibbs-Donnan effects. Compared to acrylate the dextran polymer has less sodium per gram, lower osmotic activity of polymer sodium, and yields less ultrafiltration at given transmembrane osmolalities. A non-toxic polymer more like acrylate would seem more promising as an osmotic agent for peritoneal dialysis.

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