The most common complaint of neuropathic patients is that they were unaware of the neuropathic pathway until it caused a complication. Foot treatment, protection, and amputation prevention historically have been overlooked or covered only slightly in medical education. Chronic neuropathic complications have been seen to have an unavoidable outcome. In many areas, there are no certified orthotists or local health care practitioners who are trained in off-loading techniques. The goal of treatment of a neuropathic or dysvascular patient is to preserve the limb and ambulatory function. Techniques can be shared between disciplines for improved outcomes for neuropathic patients. The combined team expertise with state-of-the-art techniques have enabled wound healing, limb salvage, and improved quality of life for this high-risk population.