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Orthostatic intolerance and postural tachycardia syndrome: new insights into pathophysiology and treatment

Authors
  • Ruzieh, Mohammed1
  • Grubb, Blair P.2
  • 1 The Pennsylvania State Heart and Vascular Institute, Cardiology, Hershey, PA, USA , Hershey (United States)
  • 2 The University of Toledo Medical Center, Division of Cardiovascular Medicine, 3000 Arlington Ave., Toledo, OH, 43614, USA , Toledo (United States)
Type
Published Article
Journal
Herzschrittmachertherapie + Elektrophysiologie
Publisher
Springer Medizin
Publication Date
Apr 25, 2018
Volume
29
Issue
2
Pages
183–186
Identifiers
DOI: 10.1007/s00399-018-0563-1
Source
Springer Nature
Keywords
License
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Abstract

Orthostatic intolerance is characterized by symptoms of light-headedness or syncope that is provoked upon standing or in an upright posture. It is most commonly caused by postural orthostatic tachycardia syndrome (POTS) or orthostatic hypotension (OH). Its pathophysiology is complex and commonly involves abnormal autonomic nervous system regulation, autoimmunity, a hyperadrenergic state, and hypovolemia. This article reviews the pathophysiology underlying orthostatic intolerance, as well as the current treatment available.

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