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Orthostatic challenge during neuroleptic test dose: a possible predictor of short-term outcome.

Authors
  • Volz, H P
  • Mackert, A
  • Diefenbacher, A
  • Friedrich, A
  • Gaebel, W
  • Müller, H
  • Stock, G
  • Möller, H J
Type
Published Article
Journal
Neuropsychobiology
Publication Date
Jan 01, 1994
Volume
30
Issue
2-3
Pages
94–100
Identifiers
PMID: 7800170
Source
Medline
License
Unknown

Abstract

Cardiovascular measurements were used as indicators of autonomic arousal during an orthostatic challenge test without medication and after a test dose of 150 mg perazine in 20 acute schizophrenic patients. Unmedicated schizophrenics showed elevated heart rates and elevated systolic and diastolic blood pressure in comparison to healthy volunteers. After a test dose of 150 mg perazine, responders (using BPRS outcome criteria after 23 days) showed a pronounced orthostatic heart rate reaction in comparison to nonresponders. Results are discussed in relation to arousal theories and central dopaminergic activity in schizophrenia.

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