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The origins and processing of ultra fine anaphase DNA bridges

Authors
  • Liu, Ying
  • Nielsen, Christian F
  • Yao, Qi
  • Hickson, Ian D1
  • 1 Centre for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen
Type
Published Article
Journal
Current Opinion in Genetics & Development
Publisher
Elsevier
Publication Date
Jan 01, 2014
Identifiers
DOI: 10.1016/j.gde.2014.03.003
Source
Elsevier
License
Unknown

Abstract

Ultra-fine DNA bridges (UFBs) are a recently identified class of mitotic DNA structures that cannot be visualized using conventional DNA staining methods (e.g. using DAPI). Their existence can currently only be revealed by immuno-fluorescent staining for proteins that bind to them, including PICH and BLM. UFBs become visible in the anaphase of mitosis, and can persist into telophase in rare cases. There are at least three different types of UFBs that can be distinguished according to the chromosomal loci from which they originate. However, it remains largely unknown how these UFBs are generated or resolved in the cell. In this article, we will review our current understanding of different types of UFBs and the potential functional role of the proteins that have been shown to be associated with them.

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