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Original Article. Effectiveness of Hemorrhagic Fever with Renal Syndrome Bivalent Vaccine in China: A Metaanalysis

Authors
  • Huang, Xiao-xia
  • Yan, Lei
  • Wang, Shi-wen
Type
Published Article
Journal
Infection International
Publisher
De Gruyter Open
Publication Date
Mar 01, 2012
Volume
1
Issue
1
Pages
46–50
Identifiers
DOI: 10.1515/ii-2017-0007
Source
De Gruyter
Keywords
License
Green

Abstract

Objective To evaluate the effectiveness of Hemorrhagic Fever with Renal Syndrome (HFRS) bivalent vaccine in field. Methods The articles on effectiveness of HFRS bivalent vaccine were retrieved from Vip Database, China Journal Full-text Database, Wanfang database, China Hospital Knowledge Database, Chinese Biomedical Literature Database, MEDLINE and ProQuest. Two persons extracted data and evaluated the quality of data together for meta-analysis. Results Seven articles were included into the analysis, and two articles were random clinical trials, five were quasi-trials. Meta-analysis showed that the overall effectiveness of HFRS bivalent vaccine was 85% (95% confidence interval: 53%-95%) within one year after vaccination, and the effectiveness in two-dose recipients and three-dose recipients was 87% (95% confidence interval: 54%-96%) and 60%, respectively; it was 96% (95% confidence interval: 78%-99%) within 2-5 years after vaccination, and the effectiveness in two-dose recipients and three-dose recipients was 95% (95% confidence interval: 19%-100%) and 96% (95% confidence interval: 70%-99%), respectively; it was 100% (only one article included) within 6-9.6 years after vaccination. The effectiveness in two-dose recipients was 88% (95% confidence interval: 62%-96%) during 1-2.5 years after vaccination, and that in three-dose recipients was 94% (95% confidence interval: 70%-99%) during 1-5 years after vaccination. Conclusions HFRS bivalent vaccine is effective in field, and there is no difference between two-dose recipients and three-dose recipients. We should do some further studies on the long-term effectiveness of HFRS bivalent vaccine and on the age of vaccine reception.

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