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Oridonin suppress cell migration via regulation of nonmuscle myosin IIA.

Authors
  • Li, Yin-Chao1
  • Sun, Mo-Ran1
  • Zhao, Yi-Hong1
  • Fu, Xian-Zu1
  • Xu, Hai-Wei2
  • Liu, Ji-Feng3
  • 1 School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, People's Republic of China.
  • 2 School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, People's Republic of China. [email protected]
  • 3 School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, People's Republic of China. [email protected]
Type
Published Article
Journal
Cytotechnology
Publication Date
May 2016
Volume
68
Issue
3
Pages
389–397
Identifiers
DOI: 10.1007/s10616-014-9790-4
PMID: 25297007
Source
Medline
Keywords
License
Unknown

Abstract

Oridonin, which is isolated from Chinese herb Rabdosia rubescens (Hemsl.) Hara, has been implicated in regulation of tumor cell migration and invasion. In this study, treatment with oridonin enhanced the phosphorylation of myosin regulatory light chain (T18/S19) that regulates the ATPase activity of myosin IIA. Meanwhile, stress fibers were significantly more prominent after oridonin incubation, which impaired cell migration in transwell migration assays. All of these effects may be caused by the decreased interaction between myosin IIA and myosin phosphatase complex, but not kinases. Our data provide clear evidence of this novel pharmacological function for oridonin in treating cancer cell migration.

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