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Oridonin suppress cell migration via regulation of nonmuscle myosin IIA

Authors
  • Li, Yin-Chao1
  • Sun, Mo-Ran1
  • Zhao, Yi-Hong1
  • Fu, Xian-Zu1
  • Xu, Hai-Wei1
  • Liu, Ji-Feng1
  • 1 Zhengzhou University, School of Pharmaceutical Sciences, 100 Kexue Avenue, Zhengzhou, 450001, People’s Republic of China , Zhengzhou (China)
Type
Published Article
Journal
Cytotechnology
Publisher
Springer-Verlag
Publication Date
Oct 09, 2014
Volume
68
Issue
3
Pages
389–397
Identifiers
DOI: 10.1007/s10616-014-9790-4
Source
Springer Nature
Keywords
License
Yellow

Abstract

Oridonin, which is isolated from Chinese herb Rabdosia rubescens (Hemsl.) Hara, has been implicated in regulation of tumor cell migration and invasion. In this study, treatment with oridonin enhanced the phosphorylation of myosin regulatory light chain (T18/S19) that regulates the ATPase activity of myosin IIA. Meanwhile, stress fibers were significantly more prominent after oridonin incubation, which impaired cell migration in transwell migration assays. All of these effects may be caused by the decreased interaction between myosin IIA and myosin phosphatase complex, but not kinases. Our data provide clear evidence of this novel pharmacological function for oridonin in treating cancer cell migration.

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