Affordable Access

Publisher Website

Organotypic human lung bud microarrays identify BMP-dependent SARS-CoV-2 infection in lung cells

Authors
  • Rosado-Olivieri, E.A.
  • Razooky, B.
  • Le Pen, J.
  • De Santis, R.
  • Barrows, D.
  • Sabry, Z.
  • Hoffmann, H.-H.
  • Park, J.
  • Carroll, T.S.
  • Poirier, J.T.
  • Rice, C.M.
  • Brivanlou, A.H.
Type
Published Article
Journal
Stem Cell Reports
Publisher
Elsevier
Publication Date
Apr 20, 2023
Volume
18
Issue
5
Pages
1107–1122
Identifiers
DOI: 10.1016/j.stemcr.2023.03.015
PMID: 37084725
PMCID: PMC10116630
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Unknown

Abstract

Brivanlou and colleagues describe a high-throughput platform to generate self-organizing human lung buds from hESCs on microchips. Lung buds display in vivo -like proximo-distal patterning of lung tissue, and are amenable to high-throughput quantitative analysis of SARS-CoV-2 cell type-specific infection, transmission, and cytopathology. Transcriptomic comparisons with COVID-19 postmortem tissues identified the BMP signaling pathway as a key regulator of SARS-CoV-2 infection.

Report this publication

Statistics

Seen <100 times