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Organ-on-a-chip platforms for evaluation of environmental nanoparticle toxicity

Authors
  • Lu, Rick Xing Ze1
  • Radisic, Milica1, 2, 3, 4
  • 1 Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada
  • 2 Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, Canada
  • 3 Toronto General Research Institute, University Health Network, Toronto, ON, Canada
  • 4 The Heart and Stroke/Richard Lewar Centre of Excellence, Toronto, ON, Canada
Type
Published Article
Journal
Bioactive Materials
Publisher
KeAi Publishing
Publication Date
Feb 15, 2021
Volume
6
Issue
9
Pages
2801–2819
Identifiers
DOI: 10.1016/j.bioactmat.2021.01.021
PMID: 33665510
PMCID: PMC7900603
Source
PubMed Central
Keywords
License
Unknown

Abstract

• The current understanding of nanotoxicity is insufficient relative to the rate of their emission in the environment and the lack of predictive platforms that mimic the human physiology. • This calls for a development of more physiologically relevant models, which permit the comprehensive and systematic examination of toxic properties of nanoparticles. • With the advancement in microfabrication techniques, scientists have shifted focused to develop an engineered system that act as an intermediate between well-plate system and animal models, known as organ-on-a-chips. • Organ-on-a-chip systems offer the potential to delineate biological mechanisms of epidemiological findings.

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