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Organometallic ruthenium and osmium compounds of pyridin-2- and -4-ones as potential anticancer agents.

Authors
  • Henke, Helena
  • Kandioller, Wolfgang
  • Hanif, Muhammad
  • Keppler, Bernhard K
  • Hartinger, Christian G
Type
Published Article
Journal
Chemistry & Biodiversity
Publisher
Wiley (John Wiley & Sons)
Publication Date
Sep 01, 2012
Volume
9
Issue
9
Pages
1718–1727
Identifiers
DOI: 10.1002/cbdv.201200005
PMID: 22976964
Source
Medline
License
Unknown

Abstract

Organometallic Ru(II) compounds are among the most widely studied anticancer agents. Functionalizing metal centers with biomolecule-derived ligands has been shown to be a promising strategy to improve the antiproliferative activity of metal-based chemotherapeutics. Herein, the synthesis of a series of novel 3-hydroxypyridin-2-one-derived ligands and their M(II)(η(6)-p-cymene) half-sandwich complexes (M = Ru, Os) is described. The compounds were characterized by 1D- and 2D-NMR spectroscopy, and elemental analysis.

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