Affordable Access

deepdyve-link
Publisher Website

Organocatalytic synthesis of N-Phenylisoxazolidin-5-ones and a one-pot synthesis of beta-amino acid esters.

Authors
  • Seayad, Jayasree
  • Patra, Pranab Kumar
  • Zhang, Yugen
  • Ying, Jackie Y
Type
Published Article
Journal
Organic Letters
Publisher
American Chemical Society
Publication Date
Mar 06, 2008
Volume
10
Issue
5
Pages
953–956
Identifiers
DOI: 10.1021/ol800003n
PMID: 18247633
Source
Medline
License
Unknown

Abstract

A novel N-heterocyclic carbene (NHC)-catalyzed C-N bond formation by the reaction of alpha,beta-unsaturated aldehydes and nitrosobenzene to N-phenylisoxazolidin-5-ones, followed by an acid-catalyzed esterification and Bamberger-like rearrangement in a mild one-pot protocol leads to N-p-methoxyphenyl (N-PMP) protected beta-amino acid esters.

Report this publication

Statistics

Seen <100 times