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The Organizing Principles of Eukaryotic Ribosome Recruitment

Authors
  • Pelletier, Jerry
  • Sonenberg, Nahum
Type
Published Article
Journal
Annual Review of Biochemistry
Publisher
Annual Reviews
Publication Date
Jun 20, 2019
Volume
88
Pages
307–335
Identifiers
DOI: 10.1146/annurev-biochem-013118-111042
Source
Annual Reviews
Keywords
License
Yellow

Abstract

The stage at which ribosomes are recruited to messenger RNAs (mRNAs) is an elaborate and highly regulated phase of protein synthesis. Upon completion of this step, a ribosome is positioned at an appropriate initiation codon and primed to synthesize the encoded polypeptide product. In most circumstances, this step commits the ribosome to translate the mRNA. We summarize the knowledge regarding the initiation factors implicated in this activity as well as review different mechanisms by which this process is conducted.

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