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Organization and evolution of a gene cluster for human immunoglobulin variable regions of the kappa type.

Authors
  • Pech, M
  • Jaenichen, H R
  • Pohlenz, H D
  • Neumaier, P S
  • Klobeck, H G
  • Zachau, H G
Type
Published Article
Journal
Journal of molecular biology
Publication Date
Jun 25, 1984
Volume
176
Issue
2
Pages
189–204
Identifiers
PMID: 6086934
Source
Medline
License
Unknown

Abstract

An 80,000 base-pair region from the gene locus encoding the variable regions of the human immunoglobulins of the kappa type (V kappa genes) was cloned and analysed. The region comprises five V kappa sequences of subgroup I and one interspersed V kappa pseudogene of subgroup II. The six genes and pseudogenes are arranged at different distances but in the same orientation. The organization of the cluster can be explained by a series of amplification steps; the existence of a V kappa II pseudogene in a V kappa I gene cluster may have been the result of a transposition event; a final duplication step led to a second closely related copy of the cluster. From sequence data for altogether 16,000 base-pairs it appears that gene conversion-like events and subsequent selection contribute to both homogeneity and diversity of the V kappa repertoire.

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