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Organic cations substituted for sodium are toxic to cultured rat glioma cells.

Authors
  • Mokrasch, L C
Type
Published Article
Journal
Molecular and cellular biochemistry
Publication Date
Jan 18, 1990
Volume
92
Issue
1
Pages
85–89
Identifiers
PMID: 2308579
Source
Medline
License
Unknown

Abstract

As a prelude to studying the sodium dependence of choline-transport systems, a number of organic compounds plus LiCl, CsCl and RbCl as sodium substitutes were tested for toxicity to maintain isoosmolality or ionic strength on cultured rat astrocytoma cells. In short term experiments (1 hour), tetramethylammonium chloride, triethanolammonium chloride, guanidinium chloride, tris hydrochloride, mannitol, sucrose, LiCl, RbCl and CsCl were well tolerated. In long term exposure (4 days), no compound was completely nontoxic as a sodium substitute, but sucrose, mannitol, LiCl, and RbCl allowed maximum cell survival.

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