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ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection

Authors
  • Hachim, Asmaa1
  • Kavian, Niloufar1, 2, 3
  • Cohen, Carolyn A.1
  • Chin, Alex W. H.1
  • Chu, Daniel K. W.1
  • Mok, Chris K. P.1
  • Tsang, Owen T. Y.4
  • Yeung, Yiu Cheong4
  • Perera, Ranawaka A. P. M.1
  • Poon, Leo L. M.1, 1
  • Peiris, J. S. Malik1, 1
  • Valkenburg, Sophie A.1
  • 1 The University of Hong Kong, Hong Kong SAR, China , Hong Kong SAR (China)
  • 2 Sorbonne Paris Cité, Assistance Publique–Hôpitaux de Paris, Hôpital Universitaire Paris Centre, Centre Hospitalier Universitaire Cochin, Service d’Immunologie Biologique, Paris, France , Paris (France)
  • 3 INSERM U1016, Université Paris Descartes, Sorbonne Paris Cité, Paris, France , Paris (France)
  • 4 Princess Margaret Hospital, Hospital Authority of Hong Kong, Hong Kong SAR, China , Hong Kong SAR (China)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Aug 17, 2020
Volume
21
Issue
10
Pages
1293–1301
Identifiers
DOI: 10.1038/s41590-020-0773-7
Source
Springer Nature
License
Yellow

Abstract

Accurate serology testing is urgently needed to help diagnose SARS-CoV-2 infection. Here Valkenburg and colleagues use a luciferase immunoprecipitation system to assess the antibody responses to 15 different SARS-CoV-2 antigens in patients with COVID-19 and find ORF8 and ORF3b antibodies, taken together as a cluster of points, identified 96.5% of COVID-19 samples at early and late time points of disease with 99.5% specificity

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