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ORC1 interacts with c-Myc to inhibit E-box-dependent transcription by abrogating c-Myc-SNF5/INI1 interaction.

Authors
  • Takayama, M A
  • Taira, T
  • Tamai, K
  • Iguchi-Ariga, S M
  • Ariga, H
Type
Published Article
Journal
Genes to cells : devoted to molecular & cellular mechanisms
Publication Date
Jun 01, 2000
Volume
5
Issue
6
Pages
481–490
Identifiers
PMID: 10886373
Source
Medline
License
Unknown

Abstract

These results suggest that ORC1 suppresses the transcription activity of c-Myc by its recruitment into an inactive form of chromatin during some stage of the cell cycle.

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