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Oral misoprostol does not hasten oviductal transport of day-5 horse embryos.

Authors
  • Checura, Celina M1
  • Momont, Harry W2
  • Castañeira, Catalina3
  • Flores-Bragulat, Ana3
  • Losinno, Luis3
  • 1 Piedmont Research and Education Center, Clemson University, Clemson, SC, USA. Electronic address: [email protected]
  • 2 School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.
  • 3 Laboratorio de Producción Equina, Universidad Nacional de Río Cuarto, Río Cuarto, Córdoba, Argentina. , (Argentina)
Type
Published Article
Journal
Animal reproduction science
Publication Date
Dec 01, 2020
Volume
223
Pages
106626–106626
Identifiers
DOI: 10.1016/j.anireprosci.2020.106626
PMID: 33137691
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

In horses, prostaglandin E2 (PGE2) is produced by embryos around Day 5 post-ovulation; PGE2 functions directly at the oviduct promoting embryo transport into the uterus. Non-surgical collection of horse embryos for cryopreservation is recommended at Day 6.5-7 post-ovulation. It was proposed that misoprostol administered orally will hasten oviductal transport of horse embryos. In Experiment 1 (n = 15) there was comparison of time of embryo recovery (Day 6 and 6.5 post-ovulation) from mares administered misoprostol (Day 5 and 5.5) orally to that of untreated mares. On Day 6, embryo collections were attempted; if no embryo was collected, there was a second attempt on Day 6.5. In Experiment 2, (n = 16) misoprostol treatment was initiated on Day 4.5; there was the first embryo collection attempt on Day 5.5, followed by Day 6 and 6.5 if no embryo was collected. Blood samples were collected at 12 h intervals on Day 4.5 or 5, to Day 6.5. In Experiment 1, on days 6 and 6.5, respectively, there was collection of seven and one of a total of eight embryos detected at the time of collection per group (P = 1). In Experiment 2, 12 embryos were collected during 15 cycles with there being a total of three, two, and one collected from mares of both groups on Day 5.5, 6, and 6.5 post-ovulation, respectively (P = 1). Serum progesterone concentrations were not different (P ≥ 0.05). In conclusion, misoprostol, when administered orally, does not hasten oviductal transport of horse embryos. Copyright © 2020 Elsevier B.V. All rights reserved.

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