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Oral lichen planus: a microbiologist point of view.

Authors
  • Villa, Tomás G1
  • Sánchez-Pérez, Ángeles2
  • Sieiro, Carmen3
  • 1 Department of Microbiology, Faculty of Pharmacy, University of Santiago de Compostela, 15706, Santiago de Compostela, EU, Spain. [email protected] , (Spain)
  • 2 Sydney School of Veterinary Science, Faculty of Science, University of Sydney, Camperdown, NSW, 2006, Australia. , (Australia)
  • 3 Department of Functional Biology and Health Sciences, Microbiology Area, Faculty of Biology, University of Vigo, 36310 Vigo, Pontevedra, EU, Spain. [email protected] , (Spain)
Type
Published Article
Journal
International Microbiology
Publisher
Springer-Verlag
Publication Date
Aug 01, 2021
Volume
24
Issue
3
Pages
275–289
Identifiers
DOI: 10.1007/s10123-021-00168-y
PMID: 33751292
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Oral lichen planus (OLP) is a chronic disease of uncertain etiology, although it is generally considered as an immune-mediated disease that affects the mucous membranes and even the skin and nails. Over the years, this disease was attributed to a variety of causes, including different types of microorganisms. This review analyzes the present state of the art of the disease, from a microbiological point of view, while considering whether or not the possibility of a microbial origin for the disease can be supported. From the evidence presented here, OLP should be considered an immunological disease, as it was initially proposed, as opposed to an illness of microbiological origin. The different microorganisms so far described as putative disease-causing agents do not fulfill Koch's postulates; they are, actually, not the cause, but a result of the disease that provides the right circumstances for microbial colonization. This means that, at this stage, and unless new data becomes available, no microorganism can be envisaged as the causative agent of lichen planus. © 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG part of Springer Nature.

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