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Oral lactoferrin for the prevention of sepsis and necrotizing enterocolitis in preterm infants.

Authors
  • Pammi, Mohan
  • Abrams, Steven A
Type
Published Article
Journal
The Cochrane database of systematic reviews
Publication Date
Jan 01, 2011
Issue
10
Identifiers
DOI: 10.1002/14651858.CD007137.pub3
PMID: 21975765
Source
Medline
License
Unknown

Abstract

Oral lactoferrin prophylaxis reduces the incidence of late-onset sepsis in infants weighing less than 1500 g and most effective in infants weighing less than 1000 g. There is no evidence of efficacy of oral lactoferrin (given alone) in the prevention of NEC in preterm neonates.Well designed, randomized trials should address dosing, duration, type of lactoferrin (bovine or human) prophylaxis in prevention of sepsis and NEC. The effect of exclusive maternal milk feeding should be clarified.

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