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Oral insulin delivery: utopia, currently possible or a near reality?

Authors
  • Pinelo, Rute1
  • Roque, Luís2
  • Reis, Catarina Pinto2, 3
  • 1 Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, Lisboa 1649003, Portugal. , (Portugal)
  • 2 iMED.ULisboa (Research Institute for Medicines), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, Lisboa 1649003, Portugal. , (Portugal)
  • 3 IBEB (Biophysics & Biomedical Engineering), Faculty of Sciences, Universidade de Lisboa, Campo Grande, Lisboa 1749016, Portugal. , (Portugal)
Type
Published Article
Journal
Therapeutic Delivery
Publisher
"Future Science, LTD"
Publication Date
Jun 01, 2021
Volume
12
Issue
6
Pages
477–488
Identifiers
DOI: 10.4155/tde-2021-0021
PMID: 34008413
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Diabetes is still one of the main diseases worldwide due to its high incidence, prevalence and, unfortunately, very high mortality. Type 1 diabetes (and in some other types) is generally controlled by exogenous insulin. Several attempts of oral insulin administration to humans have been done so far. Some of them achieved interesting results, but it seems to exist a barrier to transpose these studies into clinical trials. A broad perspective about the oral insulin and approaches will be addressed. Representative (not all) examples of innovation are herein described, and they should represent a step forward to achieve the main goal: to orally deliver insulin and improve the life quality of millions of patients.

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