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Oral gallic acid improves metabolic profile by modulating SIRT1 expression in obese mice brown adipose tissue: A molecular and bioinformatic approach.

Authors
  • Paraíso, Alanna Fernandes1
  • Sousa, Jaciara Neves2
  • Andrade, João Marcus Oliveira1
  • Mangabeira, Eloá Santos2
  • Lelis, Deborah de Farias2
  • de Paula, Alfredo Mauricio Batista2
  • Martins, Andréia Maria Eleutério Barros-...2
  • Lima, William James Nogueira3
  • Guimarães, André Luiz Sena2
  • Melo, Geraldo Aclécio4
  • Schwarz, Michaela5
  • Santos, Sérgio Henrique Sousa6
  • 1 Departament of Nursing, Faculdades Santo Agostinho, Montes Claros, Minas Gerais, Brazil; Postgraduate Program in Health Science, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil. , (Brazil)
  • 2 Postgraduate Program in Health Science, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil. , (Brazil)
  • 3 Institute of Agricultural Sciences (ICA), Food Engineering, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. , (Brazil)
  • 4 Postgraduate Program in Biology, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil. , (Brazil)
  • 5 Department of Transplantation Surgery and Section for Surgical Research, Medical University of Graz, Austria. , (Austria)
  • 6 Postgraduate Program in Health Science, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil; Institute of Agricultural Sciences (ICA), Food Engineering, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address: [email protected] , (Brazil)
Type
Published Article
Journal
Life sciences
Publication Date
Nov 15, 2019
Volume
237
Pages
116914–116914
Identifiers
DOI: 10.1016/j.lfs.2019.116914
PMID: 31622606
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The aim of the presente study was to examine the effects of oral gallic acid (GA) administration on the brown adipose tissue of obese mice fed with high-fat diet. New mechanisms and interactions pathways in thermogenesis were accessed through bioinformatics analyses. Swiss male mice were divided into four groups and fed during 60 days with: standard diet, standard diet combined with gallic acid, high-fat diet and high-fat diet combined with gallic acid. Body weight, food intake, and blood parameters (glucose tolerance test, total-cholesterol, high-density low-c, triglyceride and glucose levels) were evaluated. Brown and subcutaneous white adipose tissue histological analysis were performed. SIRT1 and PGC1-α mRNA expression in the brown adipose tissue were assessed. Our main findings showed that the gallic acid improved glucose tolerance and metabolic parameters. These results were accompanied by bioinformatics analyses that evidenced SIRT1 as main target in the thermogenesis process, confirmed as increased SIRT1 mRNA expression was evidenced in the brown adipose tissue. Together, the data suggest that the gallic acid effect in brown adipose tissue may improve body metabolism, glucose homeostasis and increase thermogenesis. Copyright © 2019 Elsevier Inc. All rights reserved.

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