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Oral disodium cromoglycate in food allergy. An open trial in four patients.

Authors
  • Esteban, M M
  • OJeda Casas, J A
  • Laso Borrego, M T
  • Marcos, C P
Type
Published Article
Journal
Acta allergologica
Publication Date
Dec 01, 1977
Volume
32
Issue
6
Pages
413–425
Identifiers
PMID: 413327
Source
Medline
License
Unknown

Abstract

The effect of DSCG olution per os was studied in four infants with immediate hypersensitivity reaction to cow's milk and egg, manifested by digestive and cutaneous symptoms. Previous administration of a 1 per cent DSCG solution by mouth resulted in diminution of both the digestive and cutaneous symptoms associated with allergen challenge. The best time interval between oral DSCG and the allergen challenge was about 30 min. The drug lost effectiveness when the solution was prepared more than a week in advance of its administration. A 2-year follow-up in two of the patients revealed the reappearance of cutaneous and digestive symptoms and, for the first time, the onset of wheezing while continuing to administer the allergens and despite continuous oral DSCG. The characteristics of these cases raise questions about the means of sensitization, and the possible mechanism of action of oral DSCG in the inhibition of non-digestive symptoms. Clinical indications for its use are discussed.

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