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Oral Desogestrel as Endometrial Preparation before Operative Hysteroscopy: A Systematic Review

Authors
  • Ciebiera, Michał
  • Zgliczyńska, Magdalena
  • Zgliczyński, Stanisław
  • Sierant, Antoni
  • Laganà, Antonio Simone
  • Alonso Pacheco, Luis
  • Carugno, Jose
  • Vitale, Salvatore Giovanni
Type
Published Article
Journal
Gynecologic and Obstetric Investigation
Publisher
S. Karger AG
Publication Date
May 05, 2021
Volume
86
Issue
3
Pages
209–217
Identifiers
DOI: 10.1159/000514584
PMID: 33951627
Source
Karger
Keywords
Disciplines
  • Systematic Review
License
Green
External links

Abstract

The pharmacologic preparation of the endometrium before hysteroscopy may be achieved with the use of various drugs. This systematic review aims to summarize the available evidence regarding the use of desogestrel for endometrial preparation before hysteroscopic procedures. A literature search for suitable articles published in English language from inception of the database until August 2019 was performed using the following databases: PubMed/MEDLINE, EMBASE, the Cochrane Library, and Google Scholar. All original articles concerning desogestrel-only pretreatment before hysteroscopic surgery were considered eligible. Reviews, case reports/series, conference papers, studies including the use of combined hormonal preparation, and articles in languages other than English were excluded from the analysis. The literature search retrieved 3 studies that met all the inclusion criteria. The data demonstrated that desogestrel may be considered as a hormonal pretreatment drug before hysteroscopic procedures. The drug was distinctly effective and assessed as helpful by the operating surgeon in numerous patients who were administered the pretreatment of 75 μg daily. Oral desogestrel is a cheap, easily available, safe, and quite efficient alternative for endometrial preparation before hysteroscopic procedures.

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