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Oral Cancer-associated Tertiary Lymphoid Structures: Gene-Expression Profile and Prognostic Value.

Authors
  • Li, Keyi1, 2, 3
  • Guo, Qingbo4
  • Zhang, Xuedong5
  • Dong, Xinqian5
  • Liu, Wei6
  • Zhang, Anqi6
  • Li, Yingxue5
  • Yan, Jinqiang5
  • Jia, Guotao5
  • Zheng, Zheng5
  • Tang, Wenqiang6
  • Pan, Li6
  • An, Meng7
  • Zhang, Bin2, 3
  • Liu, Shuwei1
  • Fu, Bo6
  • 1 Department of Human Anatomy, Histology and Embryology, Shandong University School of Medicine, Jinan, P.R, China. , (China)
  • 2 Department of Stomatology, Liaocheng People's Hospital, Liaocheng, P.R, China. , (China)
  • 3 Shandong Province Key Laboratory of Oral and Maxillofacial-Head and Neck Medicine, Liaocheng, P.R, China. , (China)
  • 4 Department of Clinical Laboratory, Yidu Central Hospital of Weifang, Weifang, P.R, China. , (China)
  • 5 Department of Pathology, Liaocheng People's Hospital, Liaocheng, P.R, China. , (China)
  • 6 Department of Central Laboratory, Liaocheng People's Hospital, Liaocheng, P.R, China. , (China)
  • 7 Department of Clinical Laboratory, Liaocheng People's Hospital, Liaocheng, P.R, China. , (China)
Type
Published Article
Journal
Clinical & Experimental Immunology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Oct 25, 2019
Identifiers
DOI: 10.1111/cei.13389
PMID: 31652350
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Tertiary lymphoid structure (TLS) provides a local and critical microenvironment for both cellular and humoral immunity and supports effective antigen presentation and lymphocyte activation. However, the gene expression profile and prognostic significance of TLS in oral cancer remain largely unrevealed. In this study, we found the presence of both intratumoral and peritumoral TLSs in a series of 65 patients with oral cancer treated by surgical resection, with the positive detection rates of 33.8% and 75.4%, respectively. The presence of intratumoral TLSs, but not peritumoral TLSs, was significantly associated with decreased P53 and Ki67 scores (P = 0.027 and 0.047, respectively). The survival analyses revealed that oral cancer patients with higher grade of TLSs was associated with improved disease-free survival (DFS) and overall survival (OS) (P = 0.037 and 0.031, respectively). Gene expression profiling analysis of the cytokines and chemokines responsible for lymph-node neogenesis identified a 3-upregulated-gene set, i.e. IL7, LTB and CXCL13, which was indicated correlated with human oral cancer-associated TLSs. This study provides a framework for better understanding of oral cancer-associated TLSs, and for delineating future innovative prognostic biomarkers and immune therapeutic strategies for oral cancer. © 2019 British Society for Immunology.

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