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Oral artesunate prevents Plasmodium berghei Anka infection in mice.

Authors
  • Gumede, Bonginkosi
  • Folb, Peter
  • Ryffel, Bernhard
Type
Published Article
Journal
Parasitology international
Publication Date
Mar 01, 2003
Volume
52
Issue
1
Pages
53–59
Identifiers
PMID: 12543147
Source
Medline
License
Unknown

Abstract

Artesunate, a semi-synthetic derivative of a naturally occurring anti-malarial artemisinin was compared with chloroquine in C57BL/6 mice infected with Plasmodium berghei Anka (PbA). A 7-day oral administration of artesunate prevented parasitaemia at 10 mg/kg/day. However, recrudescence of parasitaemia and cerebral malaria occurred upon cessation of treatment followed by death within 28 days. However, a 14-day course of artesunate (100 mg/kg/day) prevented completely the development of parasitaemia and cerebral malaria with a survival of more than 60-days as did 10 mg/kg/day chloroquine. These data demonstrate that oral artesunate inhibits PbA and prevents cerebral malaria, but needs to be administered at high dose and for prolonged time to eradicate PbA infection in mice.

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