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Optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations

  • Hersman, S
  • Cushman, J
  • Lemelson, N
  • Wassum, K
  • Lotfipour, S
  • Fanselow, MS
Publication Date
Dec 01, 2017
eScholarship - University of California
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© 2017 The Author(s). Learning about context is essential for appropriate behavioral strategies, but important contingencies may not arise during initial learning. A variant of contextual fear conditioning, context pre-exposure facilitation, allows us to directly test the relationship between novelty-induced acetylcholine release and later contextual associability. We demonstrate that optogenetically-enhanced acetylcholine during initial contextual exploration leads to stronger fear after subsequent pairing with shock, suggesting that novelty-induced acetylcholine release primes future contextual associations.

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