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Optimizing the time course of brachytherapy and other accelerated radiotherapeutic protocols.

Authors
  • Brenner, D J
  • Hall, E J
  • Huang, Y
  • Sachs, R K
Type
Published Article
Journal
International Journal of Radiation Oncology*Biology*Physics
Publisher
Elsevier
Publication Date
Jul 01, 1994
Volume
29
Issue
4
Pages
893–901
Identifiers
PMID: 8040040
Source
Medline
License
Unknown

Abstract

Difference in repair rates between early- and late-responding tissues can be exploited to produce clinically practical protocols that are significantly superior to current regimens. Such optimized protocols produce slightly better tumor control than CLDR with the same overall dose and time, significantly less late damage, and similar early normal-tissue sequellae. Temporal optimization, thus, promises to be a powerful tool in designing better treatment protocols.

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