The preparation of microcapsules of an acrylic adhesive in a solvent medium with reticulated walls of melamine-formaldehyde was studied. In order to obtain the best experimental conditions for this process, the methodology of factorial design was used. It was found that, among the 11 tested parameters, four had an important effect on the microencapsulation: amount of wall polymer, amount and nature of the copolymer, GANTREZ, and amount of adhesive in the core. The process was optimized using a surface response methodology. A layer of microcapsules deposited on paper gave, after manual breakage, very good adhesive properties.