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Optimization of iontophoretic parameters for the transdermal delivery of methotrexate.

Authors
  • Vemulapalli, Viswatej
  • Banga, Ajay K
  • Friden, Phillip M
Type
Published Article
Journal
Drug delivery
Publication Date
Sep 01, 2008
Volume
15
Issue
7
Pages
437–442
Identifiers
DOI: 10.1080/10717540802035145
PMID: 18712621
Source
Medline
License
Unknown

Abstract

The aim of this work was to study the in vitro factors affecting transdermal iontophoretic delivery of methotrexate across hairless rat skin. Initial screening studies evaluated the effect of ionic strength and donor concentration. A response surface model using factorial design shows an increase in the cumulative amount of methotrexate delivered (Y1) with an increase in current density (X1) and time of application (X2). However, 10 min iontophoresis and 0.05 mA/cm2 current density did not show an increase in delivery with an increase in current density or time of application, respectively. The factorial design was able to identify the optimal parameters that would have been difficult to predict with a conventional one at a time-experimental approach.

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