Affordable Access

Access to the full text

Optimization of Drug Administration Dosage Regimen Considering Chronorhythms and Desynchronosis of Gastrointestinal-Tract Organs

Authors
  • Bunyatyan, N. D.
  • Drogovoz, S. M.
  • Kononenko, A. V.
  • Olefir, Yu. V.
  • Prokof’ev, A. B.
Type
Published Article
Journal
Pharmaceutical Chemistry Journal
Publisher
Springer US
Publication Date
Nov 10, 2017
Volume
51
Issue
8
Pages
695–697
Identifiers
DOI: 10.1007/s11094-017-1676-2
Source
Springer Nature
Keywords
License
Yellow

Abstract

Medicinal effects on gastrointestinal-tract (GIT) organs under normal and pathological conditions are reviewed and analyzed. It is shown that rhythmic processes of digestive organs interact closely with the hierarchical structure of partial in vivo rhythms. This creates the prerequisites for prescribing medicines for GIT disorders considering individual in vivo chronorhythms and drug pharmacokinetic profiles.

Report this publication

Statistics

Seen <100 times