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Optimal Management of Acute Severe Ulcerative Colitis (ASUC): Challenges and Solutions

Authors
  • Holvoet, Tom1, 2
  • Lobaton, Triana2
  • Hindryckx, Pieter2
  • 1 AZ Nikolaas, Sint-Niklaas , (Belgium)
  • 2 University Hospital Ghent, Ghent , (Belgium)
Type
Published Article
Journal
Clinical and Experimental Gastroenterology
Publisher
Dove
Publication Date
Mar 08, 2021
Volume
14
Pages
71–81
Identifiers
DOI: 10.2147/CEG.S197719
PMID: 33727846
PMCID: PMC7955027
Source
PubMed Central
Keywords
Disciplines
  • Review
License
Green

Abstract

Acute severe colitis is a severe complication of ulcerative colitis, affecting approximately 20% of patients. For physicians, it remains a challenging condition to treat. Current treatment algorithms have diminished the mortality associated with acute severe ulcerative colitis (ASUC), but colectomy rates remain high (approximately 30%) despite advances in therapy. Colectomy in ASUC is particularly associated with important postoperative complications and morbidity. In this review, reasons for the inability to improve care and avoid evolution to colectomy for ASUC are explored and solutions that might lead to a better management of the disease are investigated.

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