Affordable Access

deepdyve-link
Publisher Website

Optimal design and experimental validation of a simulated moving bed chromatography for continuous recovery of formic acid in a model mixture of three organic acids from Actinobacillus bacteria fermentation.

Authors
  • Park, Chanhun1
  • Nam, Hee-Geun1
  • Lee, Ki Bong2
  • Mun, Sungyong3
  • 1 Department of Chemical Engineering, Hanyang University, Seoul 133-791, South Korea. , (North Korea)
  • 2 Department of Chemical and Biological Engineering, Korea University, Seoul 136-713, South Korea. Electronic address: [email protected] , (North Korea)
  • 3 Department of Chemical Engineering, Hanyang University, Seoul 133-791, South Korea. Electronic address: [email protected] , (North Korea)
Type
Published Article
Journal
Journal of chromatography. A
Publication Date
Oct 24, 2014
Volume
1365
Pages
106–114
Identifiers
DOI: 10.1016/j.chroma.2014.09.005
PMID: 25240652
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The economically-efficient separation of formic acid from acetic acid and succinic acid has been a key issue in the production of formic acid with the Actinobacillus bacteria fermentation. To address this issue, an optimal three-zone simulated moving bed (SMB) chromatography for continuous separation of formic acid from acetic acid and succinic acid was developed in this study. As a first step for this task, the adsorption isotherm and mass-transfer parameters of each organic acid on the qualified adsorbent (Amberchrom-CG300C) were determined through a series of multiple frontal experiments. The determined parameters were then used in optimizing the SMB process for the considered separation. During such optimization, the additional investigation for selecting a proper SMB port configuration, which could be more advantageous for attaining better process performances, was carried out between two possible configurations. It was found that if the properly selected port configuration was adopted in the SMB of interest, the throughout and the formic-acid product concentration could be increased by 82% and 181% respectively. Finally, the optimized SMB process based on the properly selected port configuration was tested experimentally using a self-assembled SMB unit with three zones. The SMB experimental results and the relevant computer simulation verified that the developed process in this study was successful in continuous recovery of formic acid from a ternary organic-acid mixture of interest with high throughput, high purity, high yield, and high product concentration. Copyright © 2014 Elsevier B.V. All rights reserved.

Report this publication

Statistics

Seen <100 times