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[Optically active barbiturates. Synthesis, configuration and pharmacological effects (author's transl)].

Authors
  • Knabe, J
  • Rummel, W
  • Büch, H P
  • Franz, N
Type
Published Article
Journal
Arzneimittel-Forschung
Publication Date
Jan 01, 1978
Volume
28
Issue
7
Pages
1048–1056
Identifiers
PMID: 385006
Source
Medline
License
Unknown

Abstract

Optically active N-alkylated barbiturates are synthesized from disubstituted cyanoacetates. The configuration of the synthesized compounds is determined by chemical and chiroptical procedures and by X-ray analysis. In animals the barbiturates show a different anesthetic activity, in some cases the CNS activity is opposed, one enantiomer is anesthetically active, the other is a convulsive agent. In their pharmacokinetic behaviour the enantiomers show remarkable differences.

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