To evaluate the refractive outcome after combined surgery of silicone oil removal with phacoemulsification and intraocular lens implantation. We calculated ocular lens implantation power with optical low-coherence reflectometry (Lenstar LS900; Haag Streit, Koniz, Switzerland) in silicone oil-filled eyes. Prospective, comparative study. The intraocular lens power of 35 silicone oil-filled eyes of 35 patients was calculated with a Lenstar LS900 laser biometer. In all cases we performed a combined procedure of pars plana vitrectomy with silicone oil removal and phacoemulsification with intraocular lens implantation. We analyzed the spherical equivalent of predicted and postoperative refractive error. A control group consisted of 25 cases of cataract extraction and intraocular lens implantation in non-vitrectomized eyes. The mean deviation of the final refraction was -0.03 ± 1.06 diopters and did not differ significantly from non-vitrectomized eyes (P < 0.05). 68.6% eyes had a deviation of ±1 diopter. There were no differences between high myopic and emmetropic silicone oil-filled eyes (-0.05 ±1.33 diopters vs. -0.03 ± 1.00 diopters; P < 0.05). Optical low-coherence reflectometry enables accurate intraocular lens power calculations in silicone oil-filled eyes. The refractive outcome is as accurate as in non-vitrectomized eyes.