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Optical imaging of acute epileptic networks in mice.

Authors
  • Guevara, Edgar1
  • Pouliot, Philippe
  • Nguyen, Dang Khoa
  • Lesage, Frédéric
  • 1 École Polytechnique de Montréal, Department of Electrical Engineering, C.P. 6079 succ. Centre-ville, Montréal, Quebec H3C 3A7, Canada. , (Canada)
Type
Published Article
Journal
Journal of Biomedical Optics
Publisher
SPIE - International Society for Optical Engineering
Publication Date
Jul 01, 2013
Volume
18
Issue
7
Pages
76021–76021
Identifiers
DOI: 10.1117/1.JBO.18.7.076021
PMID: 23887480
Source
Medline
License
Unknown

Abstract

The potential of intrinsic optical imaging and resting-state analysis under anesthetized conditions as a tool to study brain networks associated with epileptic seizures is investigated. Using an acute model of epileptiform activity, the 4-aminopyridine model in live mice, we observe the changes in resting-state networks with the onset of seizure activity and in conditions of spiking activity. Resting-state networks identified before and after the onset of epileptiform activity show both decreased and increased homologous correlations, with a small dependence on seizure intensity. The observed changes are not uniform across the different hemodynamic measures, suggesting a potential decoupling between blood flow and metabolism in the low-frequency networks. This study supports the need for a more extensive investigation of epileptic networks including more than one independent hemodynamic measurement.

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