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The Opioid-Addicted Tetrapartite Synapse.

Authors
  • Kruyer, Anna1
  • Chioma, Vivian C1
  • Kalivas, Peter W2
  • 1 Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina.
  • 2 Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina. Electronic address: [email protected]
Type
Published Article
Publication Date
Jan 01, 2020
Volume
87
Issue
1
Pages
34–43
Identifiers
DOI: 10.1016/j.biopsych.2019.05.025
PMID: 31378302
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Opioid administration in preclinical models induces long-lasting adaptations in reward and habit circuitry. The latest research demonstrates that in the nucleus accumbens, opioid-induced excitatory synaptic plasticity involves presynaptic and postsynaptic elements as well as adjacent astroglial processes and the perisynaptic extracellular matrix. We outline opioid-induced modifications within each component of the tetrapartite synapse and provide a neurobiological perspective on how these adaptations converge to produce addiction-related behaviors in rodent models. By incorporating changes observed at each of the excitatory synaptic compartments into a unified framework of opioid-induced glutamate dysregulation, we highlight new avenues for restoring synaptic homeostasis that might limit opioid craving and relapse vulnerability. Copyright © 2019 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

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