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Opioid Receptors Gene Polymorphism and Heroin Dependence in Iran.

Authors
  • Soleimani Asl, Sara1
  • Roointan, Amir2
  • Bergen, Hugo3
  • Amiri, Shayan4
  • Mardani, Parastoo5
  • Ashtari, Niloufar3
  • Shabani, Ronak6
  • Mehdizadeh, Mehdi6
  • 1 Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. , (Iran)
  • 2 Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran. , (Iran)
  • 3 Department of Human Anatomy and Cell Sciences, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. , (Canada)
  • 4 Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. , (Iran)
  • 5 Department of Biology, Faculty of Science, Tehran Branch, Payame Noor University, Tehran, Iran. , (Iran)
  • 6 Cellular and Molecular Research Center, Department of Anatomy, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran. , (Iran)
Type
Published Article
Journal
Basic and clinical neuroscience
Publication Date
Jan 01, 2018
Volume
9
Issue
2
Pages
101–106
Identifiers
DOI: 10.29252/nirp.bcn.9.2.101
PMID: 29967669
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Genes often have multiple polymorphisms that interact with each other and the environment in different individuals. Variability in the opioid receptors can influence opiate withdrawal and dependence. In humans, A118G Single Nucleotide Polymorphisms (SNP) on μ-Opioid Receptor (MOR), 36 G>T in κ-Opioid Receptor (KOR), and T921C in the δ-Opioid Receptor (DOR) have been found to associate with substance dependence. To investigate the association between opioid receptors gene polymorphism and heroin addiction, 100 control subjects with no history of opioid use, and 100 heroin addicts (50% males and 50% females) in Tehran (capital of Iran), were evaluated. A118G, 36 G>T, and T921C SNPs on the MOR, KOR, DOR genes, respectively, were genotyped by sequencing. We found no differences in either allele or genotype frequency for MOR, KOR and DOR genes SNPs between controls and subjects addicted to heroin. The relationships among polymorphisms may be important in determining the risk profile for complex diseases such as addiction, but opioid addiction is a multifactorial syndrome which is partially hereditary and partially affected by the environment.

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