Affordable Access

Publisher Website

Oocyte cumulus complex quality and oviduct transportation velocity in systemic autoimmune disease model mice.

Authors
  • Hosotani, Marina1
  • Ichii, Osamu2, 3
  • Watanabe, Takafumi1
  • Kon, Yasuhiro2
  • 1 Laboratory of Veterinary Anatomy, Department of Veterinary Medicine, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu 069-8501, Japan. , (Japan)
  • 2 Laboratory of Anatomy, Department of Basic Veterinary Science, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan. , (Japan)
  • 3 Laboratory of Agrobiomedical Science, Faculty of Agriculture, Hokkaido University, Sapporo 060-0818, Japan. , (Japan)
Type
Published Article
Journal
Experimental biology and medicine (Maywood, N.J.)
Publication Date
Aug 01, 2023
Volume
248
Issue
16
Pages
1359–1363
Identifiers
DOI: 10.1177/15353702231160875
PMID: 36961243
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Oocyte transportation by the oviduct involves the interaction between ciliated epithelial cells and cumulus cells. To determine whether the quality of cumulus-oocyte complexes (COCs) changes the transportation property of COCs, we compared the transportation velocity of COCs (TVC) by the infundibulum ex vivo with various combinations of infundibula and COCs collected from different mice. We used young and aged C57BL/6N and MRL/MpJ, and MRL/MpJ-Faslpr/lpr mice as the strains with intact female reproductive function and the systemic autoimmune disease model exhibiting oocyte pick-up dysfunction owing to the morphofunctional abnormality of ciliated epithelium, respectively. The TVC of aged MRL strains was less than that of aged C57BL/6N mice, suggesting that aging affects the transportation of COCs in MRL strains. The TVC of aged MRL/MpJ-Faslpr/lpr mice was the least among all examined combinations, whereas the TVC accelerated when the infundibulum or COCs were collected from other strains. These results indicate that the transportation property of COCs is determined not only by the ciliary function in the infundibulum but also by the properties of COCs.

Report this publication

Statistics

Seen <100 times