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Ontogenetic modifications of neuronal excitability during brain maturation: developmental changes of neurotransmitter receptors.

Authors
  • Aronica, Eleonora
  • Iyer, Anand
  • Zurolo, Emanuele
  • Gorter, Jan A
Type
Published Article
Journal
Epilepsia
Publication Date
Oct 01, 2011
Volume
52 Suppl 8
Pages
3–5
Identifiers
DOI: 10.1111/j.1528-1167.2011.03222.x
PMID: 21967348
Source
Medline
License
Unknown

Abstract

The development of the human brain depends on a precisely orchestrated cascade of events, including proliferation, migration and maturation of neural progenitor cells. Different mechanisms coordinate these stages to reach a normal structural organization, producing appropriate excitatory and inhibitory networks. Here, we will briefly review the developmental changes of glutamate (Glu) and γ-aminobutyric acid (GABA) receptors, with particular attention to the development of the human brain. We will also briefly discuss recent evidence on the involvement of the endocannabinoid signaling in the regulation of neuronal excitability during early brain development..

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