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Online sample preconcentration in capillary electrophoresis using analyte focusing by micelle collapse.

Authors
  • Quirino, Joselito P
  • Haddad, Paul R
Type
Published Article
Journal
Analytical Chemistry
Publisher
American Chemical Society
Publication Date
Sep 01, 2008
Volume
80
Issue
17
Pages
6824–6829
Identifiers
DOI: 10.1021/ac801258r
PMID: 18671411
Source
Medline
License
Unknown

Abstract

A dimension for online sample preconcentration in capillary electrophoresis (CE) without modification of current CE commercial instrumentation is introduced. The focusing mechanism is based on the transport, release, and accumulation of molecules bound to micelle carriers that are made to collapse into a liquid phase zone. More than 2 orders of magnitude improvement in detection sensitivity for model steroidal compounds using sodium dodecyl sulfate micelles as carrier is demonstrated.

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