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Ongoing evolution of hepatitis B virus during viremia in patients with febrile in Central Africa.

Authors
  • Abe, Haruka1
  • Ushijima, Yuri1
  • Bikangui, Rodrigue2, 3
  • Loembe, Marguerite M2, 3, 4
  • Agnandji, Selidji T2, 3
  • de Vries, Sophia G5
  • Grobusch, Martin P2, 3, 5
  • Lell, Bertrand2, 3, 6
  • Yasuda, Jiro1, 7, 8
  • 1 Department of Emerging Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan. , (Japan)
  • 2 Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon. , (Gabon)
  • 3 Institute for Tropical Medicine, University of Tübingen, Tübingen, Germany. , (Germany)
  • 4 Université des Sciences de la Santé de Libreville, Libreville, Gabon. , (Gabon)
  • 5 Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands. , (Netherlands)
  • 6 Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria. , (Austria)
  • 7 National Research Center for the Control and Prevention of Infectious Diseases (CCPID), Nagasaki University, Nagasaki, Japan. , (Japan)
  • 8 Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. , (Japan)
Type
Published Article
Journal
Journal of Medical Virology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Feb 01, 2020
Volume
92
Issue
2
Pages
251–256
Identifiers
DOI: 10.1002/jmv.25598
PMID: 31538666
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Hepatitis B virus (HBV) infection remains to be a major public health issue worldwide, although there is currently a safe vaccine and effective antiviral treatments. In surveillance of infectious diseases in Gabon, HBV viremia was detected in patients with febrile. Whole-genome sequencing was conducted to characterize the HBV strains currently circulating in Gabon and to investigate HBV genome diversity during viremia. Phylogenetic analysis revealed the existence of former subgenotype A5, which exhibits a particular pattern of distribution from several West and Central African countries to Haiti. Furthermore, sequencing analysis identified two similar HBV strains mixed in one sample, and a very rare 1-base pair insertion in the viral precore region. This insertion caused a frameshift mutation, indicating the production of an aberrant fusion protein of the HBV x and e antigens. Our data showed that the detected HBV strain was possibly in an "evolving" state during viremia, a phase of active replication. © 2019 Wiley Periodicals, Inc.

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