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One-step synthesis of sub-2 μm vinyl functionalized silica sphere as stationary phase for liquid chromatography.

Authors
Type
Published Article
Journal
Talanta
0039-9140
Publisher
Elsevier
Publication Date
Volume
134
Pages
425–434
Identifiers
DOI: 10.1016/j.talanta.2014.11.044
PMID: 25618689
Source
Medline
Keywords
  • Cycle-Model
  • High Performance Liquid Chromatography
  • Stationary Phase
  • Sub-2μM Vinyl-Functionalized Silica Sphere
  • Thiol-Ene Reaction

Abstract

Vinyl-functionalized silica spheres (VFSS) were synthesized through the one-step method. The effects of reactant ratio, temperature, reaction time and ammonium hydroxide dripping speed were investigated. The diameter of the spheres reached sub-2 μm magnitude by controlling the reaction conditions, which is suitable for high performance liquid chromatography (HPLC) packing material. The vinyl groups in the silica spheres were further successfully modified by octadecyl (C18) groups through a "thiol-ene" click reaction. Raw VFSS and C18modified VFSS (C-VFSS) were used as HPLC stationary phases to separate benzene homologs (benzene, toluene, and meta-xylene) and nonpolar compounds with different ring contents (benzene, phenantherene and fluoranthene). Both VFSS and C-VFSS exhibited hydrophobic retention behavior. Additionally, vinyl groups in the silica spheres may offer a π-π electron-donor-acceptor (EDA) retention mechanism for chromatographic separation.

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