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One-month apparent diffusion coefficient correlates with response to radiofrequency ablation of hepatocellular carcinoma

Authors
  • Barat, Maxime
  • Fohlen, Audrey
  • Cassinotto, Christophe
  • Jannot, Anne Sophie
  • Dautry, Raphael
  • Pelage, Jean-Pierre
  • Boudiaf, Mourad
  • Marc Pocard
  • Eveno, Clarisse
  • Taouli, Bachir
  • Soyer, Philippe
  • Dohan, Anthony
Type
Published Article
Journal
Journal of Magnetic Resonance Imaging
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jun 25, 2017
Identifiers
DOI: 10.1002/jmri.25521
Source
USPC - SET - SVS
License
White

Abstract

Purpose To assess whether apparent diffusion coefficient (ADC) values at 1 and 3 months after radiofrequency ablation (RFA) may be associated with a favorable response to therapy for hepatocellular carcinoma (HCC) and liver metastases. Materials and Methods Fifty‐nine patients with HCC (n = 35) or liver metastases (n = 24) who underwent 1.5T diffusion‐weighted magnetic resonance imaging (DWMRI) at 1 and 3 months post‐RFA were included. ADC values of patients with local tumor recurrence were compared to those without local recurrence. A subgroup analysis was performed for HCC and metastases. Results Thirty‐eight HCC and 27 metastases were evaluated. The ADC value of HCC at 1 month after RFA was lower in recurrent tumors (0.957 ± 0.229 [SD] × 10−3mm2) compared to tumors with complete response (1.414 ± 0.322 [SD] × 10−3 mm2/s, P = 0.006). At multivariate analysis, ADC at 1 month was the single independent variable associated with recurrence for HCC (area under the receiver operating characteristic curve = 0.860). No significant association was observed for liver metastases (P = 0.089). Conclusion A low ADC value at 1 month after RFA is associated with an early local recurrence of HCC. This study does not confirm that such association exists for hepatic metastases.

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