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One misdated sequence of rabbit hemorrhagic disease virus prevents accurate estimation of its nucleotide substitution rate.

Authors
  • Hicks, Allison L1
  • Duffy, Siobain
  • 1 Department of Ecology, Evolution, and Natural Resources, School of Environmental and Biological Sciences Rutgers, The State University of New Jersey, 14 College Farm Rd, New Brunswick, NJ 08901, USA.
Type
Published Article
Journal
BMC Evolutionary Biology
Publisher
Springer (Biomed Central Ltd.)
Publication Date
May 30, 2012
Volume
12
Pages
74–74
Identifiers
DOI: 10.1186/1471-2148-12-74
PMID: 22646287
Source
Medline
License
Unknown

Abstract

After excluding the misdated taxon, both genes support a significantly higher substitution rate as well as a relatively recent emergence of RHDV, and obviate the need for previously hypothesized decades of unobserved diversification of the virus. The control methods show that using even one misdated taxon in a large dataset can significantly skew estimates of evolutionary parameters and suggest that it is better practice to use smaller datasets composed of taxa with unequivocal isolation dates. These jackknife controls would be useful for future tip-calibrated rate analyses that include taxa with ambiguous dates of isolation.

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