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One locus with two roles: microRNA-independent functions of microRNA-host-gene locus-encoded long noncoding RNAs.

Authors
  • Sun, Qinyu1
  • Song, You Jin1
  • Prasanth, Kannanganattu V1, 2
  • 1 Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
  • 2 Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Type
Published Article
Journal
Wiley Interdisciplinary Reviews - RNA
Publisher
Wiley (John Wiley & Sons)
Publication Date
May 01, 2021
Volume
12
Issue
3
Identifiers
DOI: 10.1002/wrna.1625
PMID: 32945142
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Long noncoding RNAs (lncRNAs) are RNA transcripts longer than 200 nucleotides that do not code for proteins. LncRNAs play crucial regulatory roles in several biological processes via diverse mechanisms and their aberrant expression is associated with various diseases. LncRNA genes are further subcategorized based on their relative organization in the genome. MicroRNA (miRNA)-host-gene-derived lncRNAs (lnc-MIRHGs) refer to lncRNAs whose genes also harbor miRNAs. There exists crosstalk between the processing of lnc-MIRHGs and the biogenesis of the encoded miRNAs. Although the functions of the encoded miRNAs are usually well understood, whether those lnc-MIRHGs play independent functions are not fully elucidated. Here, we review our current understanding of lnc-MIRHGs, including their biogenesis, function, and mechanism of action, with a focus on discussing the miRNA-independent functions of lnc-MIRHGs, including their involvement in cancer. Our current understanding of lnc-MIRHGs strongly indicates that this class of lncRNAs could play important roles in basic cellular events as well as in diseases. This article is categorized under: Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs Regulatory RNAs/RNAi/Riboswitches > Biogenesis of Effector Small RNAs. © 2020 Wiley Periodicals LLC.

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